Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999541 | 1.00 | EGFR (0.52) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL6993881 | 0.93 | EGFR (0.56) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL7001817 | 0.93 | BRAF (0.53) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL6993890 | 0.93 | EGFR (0.56) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL6988137 | 0.93 | BRAF (0.53) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8314236 | 0.87 | BRAF (0.54) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8314239 | 0.87 | BRAF (0.54) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8315965 | 0.86 | EGFR (0.57) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8315973 | 0.86 | EGFR (0.57) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8800657 | 0.84 | BRAF (0.56) | EGFRERBB2HPGDHTTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |