Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 13/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998272 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL6997972 | 0.87 | PTGS2 (0.36) | PTGS2PTGS1MAOAMAOB | |
| SCHEMBL6998585 | 0.83 | PTGS2 (0.39) | PTGS2PTGS1 | |
| SCHEMBL7004184 | 0.82 | PTGS2 (0.46) | PTGS2PTGS1MAOAMAOB | |
| SCHEMBL6992672 | 0.82 | PTGS2 (0.51) | PTGS2PTGS1MAOAMAOB | |
| SCHEMBL6995948 | 0.81 | PTGS2 (0.39) | PTGS2PTGS1 | |
| SCHEMBL6993233 | 0.80 | PTGS2 (0.49) | PTGS2PTGS1 | |
| Polmacoxib SCHEMBL29351757 | 0.79 | PTGS2 (0.55) | PTGS2PTGS1 | |
| Polmacoxib SCHEMBL3233093 | 0.79 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL6993821 | 0.79 | PTGS2 (0.50) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |