Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 13/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000816 | 0.85 | CCR1 (0.47) | CCR1LMNATP53PTGDR2FPR3 | |
| SCHEMBL7000591 | 0.84 | CCR1 (0.62) | CCR1PTGDR2FPR3GPR65GPR35 | |
| SCHEMBL6999302 | 0.83 | CCR1 (0.64) | CCR1FPR3GPR65GPR35 | |
| SCHEMBL7091273 | 0.82 | CCR1 (0.51) | CCR1FPR3GPR65GPR35 | |
| SCHEMBL7144980 | 0.81 | CCR1 (0.61) | CCR1PTGDR2FPR3GPR65GPR35 | |
| SCHEMBL7095494 | 0.79 | CCR1 (0.51) | CCR1FPR3GPR65GPR35 | |
| SCHEMBL4634635 | 0.77 | HSD11B1 (0.55) | CCR1LMNAHTT | |
| SCHEMBL4587093 | 0.77 | CCR1 (1.00) | CCR1PTGDR2FPR3GPR65GPR35 | |
| SCHEMBL4587102 | 0.77 | CCR1 (1.00) | CCR1PTGDR2FPR3GPR65GPR35 | |
| SCHEMBL5971999 | 0.77 | CCR1 (1.00) | CCR1PTGDR2FPR3GPR65GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326867-A2 | BRIDGED PIPERAZINE DERIVATIVES | Pfizer Products Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032901-A2 | BRIDGED PIPERAZINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2002-04-25 | — | — | WO | disclosed |