Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30387136 | 0.91 | MAPKAPK2 (0.40) | MAPKAPK2GSK3BDYRK1ASCN9ACYP17A1 | |
| SCHEMBL7002099 | 0.91 | MAPKAPK2 (0.40) | MAPKAPK2GSK3BDYRK1ASCN9ACYP17A1 | |
| SCHEMBL3888187 | 0.84 | LCK (0.39) | MAPKAPK2GSK3BDYRK1ASCN9ACYP17A1 | |
| SCHEMBL29112758 | 0.82 | CNR2 (0.41) | MAPKAPK2GSK3BDYRK1ASCN9ACYP17A1 | |
| SCHEMBL23107173 | 0.81 | ATR (0.40) | MAPKAPK2GSK3BDYRK1ASCN9ACYP17A1 | |
| SCHEMBL29604131 | 0.81 | ATR (0.40) | MAPKAPK2GSK3BDYRK1ASCN9ACYP17A1 | |
| SCHEMBL29703940 | 0.81 | GSK3B (0.39) | MAPKAPK2GSK3BDYRK1ASCN9ACYP17A1 | |
| SCHEMBL25751520 | 0.81 | GSK3B (0.39) | MAPKAPK2GSK3BDYRK1ASCN9ACYP17A1 | |
| SCHEMBL6059352 | 0.80 | LCK (0.40) | MAPKAPK2GSK3BDYRK1ASCN9ACYP17A1 | |
| SCHEMBL27731447 | 0.77 | GSK3B (0.39) | MAPKAPK2GSK3BDYRK1ASCN9ALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| US-6277851-B1 | ORALLY ADMINISTERED TRYPSIN-RELATED SERINE PROTEASE INHIBITORS; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-08-21 | — | — | US | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |