Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24317924 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1KDM4EHTTNFE2L2 | |
| SCHEMBL10428522 | 0.82 | CA1 (0.48) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL5270439 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1KDM4ENFE2L2CA12 | |
| SCHEMBL23966150 | 0.80 | MAPT (0.52) | ALDH1A1KDM4ECA12CA1CA2 | |
| Nitrogen SCHEMBL10986776 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1KDM4ENFE2L2CA12 | |
| SCHEMBL24315696 | 0.76 | CA12 (0.44) | SMN1; SMN2ALDH1A1KDM4ECA12CA1 | |
| SCHEMBL2028142 | 0.76 | NFE2L2 (0.44) | SMN1; SMN2ALDH1A1KDM4ENFE2L2CA12 | |
| SCHEMBL28458116 | 0.76 | ESR1 (0.50) | SMN1; SMN2ALDH1A1CA12CA1CA2 | |
| Propane SCHEMBL27582651 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1KDM4ENFE2L2CA12 | |
| SCHEMBL29004607 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1KDM4ENFE2L2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003749-B1 | 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h/2,3/BENZODIAZEPINE DERIVATES, AS AMPA/KAINATERECEPTOR INHIBITORS | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2003-10-22 | — | — | EP | disclosed |
| US-6562810-B1 | Competitive AMPA/kainite antagonist properties making them useful in the treatment of diseases where inhibition of the AMPA/kainite receptors may a favorable effect | EGIS GYOGYSZERGYAR RT. (HU) | 2003-05-13 | — | — | US | disclosed |
| EP-1003749-A1 | 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h/2,3/BENZODIAZEPINE DERIVATES, AS AMPA/KAINATERECEPTOR INHIBITORS | EGIS GYOGYSZERGYAR RT. (HU) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999007707-A1 | 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE DERIVATIVES, AS AMPA/KAINATE RECEPTOR INHIBITORS | EGIS Gyógyszergyár Rt. (HU) | 1999-02-18 | — | — | WO | disclosed |