Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6433050 | 0.88 | PLAU (0.67) | PLAUALDH1A1TSHRPOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6999930 | 0.83 | PLAU (0.68) | PLAUALDH1A1TSHRKDM4EHTT | |
| SCHEMBL6438379 | 0.81 | PLAU (0.67) | PLAUALDH1A1TSHRPOLBGBA1 | |
| Hydrochloric Acid SCHEMBL6995674 | 0.80 | PLAU (0.66) | PLAUALDH1A1TSHRPOLBGBA1 | |
| SCHEMBL2592677 | 0.76 | PLAU (0.54) | PLAUALDH1A1TSHRPOLBGBA1 | |
| SCHEMBL6433525 | 0.75 | PLAU (0.48) | PLAUALDH1A1 | |
| SCHEMBL3149654 | 0.75 | POLB (0.72) | ALDH1A1POLBSMN1; SMN2GAALMNA | |
| SCHEMBL30693019 | 0.75 | POLB (0.72) | ALDH1A1POLBSMN1; SMN2GAALMNA | |
| SCHEMBL6993186 | 0.74 | PLAU (0.65) | PLAUALDH1A1 | |
| SCHEMBL20524688 | 0.74 | ALDH1A1 (0.74) | PLAUALDH1A1POLBSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |
| EP-1023268-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020608-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |