Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 12/20 | 0.47 |
| ▸ | FNTB | P49356 | 12/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000432 | 1.00 | FNTA (0.47) | FNTAFNTBPOLBGAAKDM4E | |
| SCHEMBL7002866 | 0.89 | FNTA (0.61) | FNTAFNTB | |
| SCHEMBL7002864 | 0.89 | FNTA (0.61) | FNTAFNTB | |
| SCHEMBL7000434 | 0.87 | FNTA (0.61) | FNTAFNTB | |
| SCHEMBL6995656 | 0.77 | FNTA (0.48) | FNTAFNTB | |
| SCHEMBL6995653 | 0.77 | FNTA (0.48) | FNTAFNTB | |
| SCHEMBL6999410 | 0.76 | FNTA (0.75) | FNTAFNTB | |
| SCHEMBL7002868 | 0.76 | FNTA (0.78) | FNTAFNTB | |
| SCHEMBL6995407 | 0.66 | FNTA (0.75) | FNTAFNTB | |
| SCHEMBL6995097 | 0.64 | FNTA (0.74) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021448-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6130229-A | Tricyclic compounds having activity as RAS-FPT inhibitors | SCHERING CORPORATION (US) | 2000-10-10 | — | — | US | disclosed |