Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 17/20 | 0.61 |
| ▸ | FNTB | P49356 | 17/20 | 0.61 |
| ▸ | HRAS | P01112 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002864 | 1.00 | FNTA (0.61) | FNTAFNTBHRASKRAS | |
| SCHEMBL7000432 | 0.89 | FNTA (0.47) | FNTAFNTB | |
| SCHEMBL7000433 | 0.89 | FNTA (0.47) | FNTAFNTB | |
| SCHEMBL6999410 | 0.88 | FNTA (0.75) | FNTAFNTBHRASKRAS | |
| SCHEMBL7002868 | 0.87 | FNTA (0.78) | FNTAFNTB | |
| SCHEMBL6994980 | 0.77 | FNTA (0.64) | FNTAFNTB | |
| SCHEMBL6994976 | 0.77 | FNTA (0.64) | FNTAFNTB | |
| SCHEMBL6999405 | 0.76 | FNTA (1.00) | FNTAFNTBHRASKRAS | |
| SCHEMBL6999407 | 0.76 | FNTA (1.00) | FNTAFNTBHRASKRAS | |
| SCHEMBL7000434 | 0.76 | FNTA (0.61) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021448-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6130229-A | Tricyclic compounds having activity as RAS-FPT inhibitors | SCHERING CORPORATION (US) | 2000-10-10 | — | — | US | disclosed |