SCHEMBL7000759

SCHEMBL7000759

COc1ccccc1C(=O)NC(=O)O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSD P07339 1/20 0.66
RAB9A P51151 4/20 0.65
NPC1 O15118 3/20 0.65
STAT3 P40763 1/20 0.62
HPGD P15428 3/20 0.61
TP53 P04637 1/20 0.61
GLA P06280 1/20 0.61
KMT2A Q03164 2/20 0.60
MEN1 O00255 1/20 0.60
ALDH1A1 P00352 2/20 0.59
SMN1; SMN2 Q16637 2/20 0.58
KCNK3 O14649 1/20 0.58
KCNK9 Q9NPC2 1/20 0.58
MAPT P10636 2/20 0.57
GAA P10253 2/20 0.57
TSHR P16473 1/20 0.57
MAPK1 P28482 1/20 0.57
HSD17B10 Q99714 1/20 0.57
RXFP1 Q9HBX9 1/20 0.57
LMNA P02545 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27495783 0.87 STAT3 (0.80) CTSDRAB9ANPC1STAT3HPGD
SCHEMBL11272638 0.84 CTSD (0.69) CTSDRAB9ANPC1STAT3HPGD
SCHEMBL7455359 0.83 CTSD (0.63) CTSDRAB9ANPC1STAT3HPGD
SCHEMBL8432518 0.83 STAT3 (0.59) CTSDRAB9ANPC1STAT3HPGD
SCHEMBL6671288 0.81 CTSD (0.70) CTSDRAB9ANPC1STAT3HPGD
SCHEMBL353828 0.81 CTSD (0.70) CTSDRAB9ANPC1STAT3HPGD
SCHEMBL27766567 0.81 CTSD (0.65) CTSDRAB9ANPC1STAT3HPGD
SCHEMBL5438647 0.80 CTSD (0.55) CTSDRAB9ANPC1STAT3HPGD
SCHEMBL5438643 0.80 CTSD (0.55) CTSDRAB9ANPC1STAT3HPGD
SCHEMBL5438640 0.80 CTSD (0.55) CTSDRAB9ANPC1STAT3HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0874809-B1 CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2003-08-27 EP claimed
US-6239175-B1 Carbamoyloxy derivatives of mutiline and their use as antibacterials SMITHKLINE BEECHAM P.L.C. (GB) 2001-05-29 US claimed
EP-0874809-B1 CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2003-08-27 EP disclosed
US-6239175-B1 Carbamoyloxy derivatives of mutiline and their use as antibacterials SMITHKLINE BEECHAM P.L.C. (GB) 2001-05-29 US disclosed
US-6020368-A MICROBIOCIDES HINKS JEREMY DAVID (US) 2000-02-01 US disclosed
EP-0874809-A1 CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 1998-11-04 EP disclosed
WO-1997025309-A1 CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 1997-07-17 WO disclosed
US-3933858-A INSECTICIDES CIBA-GEIGY AG (CH) 1976-01-20 US disclosed