Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | CASP3 | P42574 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 1/20 | 0.78 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.78 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.78 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.78 |
| ▸ | MAOB | P27338 | 4/20 | 0.68 |
| ▸ | MIF | P14174 | 3/20 | 0.68 |
| ▸ | MAOA | P21397 | 2/20 | 0.68 |
| ▸ | APP | P05067 | 1/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.61 |
| ▸ | TNF | P01375 | 2/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | STK17B | O94768 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000852 | 1.00 | MAPT (0.78) | MAPTSMN1; SMN2CASP3RAB9ASENP8 | |
| SCHEMBL8549041 | 0.87 | MAPT (1.00) | MAPTSMN1; SMN2CASP3RAB9ASENP8 | |
| SCHEMBL8549042 | 0.87 | MAPT (1.00) | MAPTSMN1; SMN2CASP3RAB9ASENP8 | |
| SCHEMBL7701180 | 0.85 | MAPT (0.79) | MAPTSMN1; SMN2CASP3RAB9ASENP8 | |
| SCHEMBL7701179 | 0.85 | MAPT (0.79) | MAPTSMN1; SMN2CASP3RAB9ASENP8 | |
| SCHEMBL14033556 | 0.82 | MIF (0.81) | MAPTMAOBMIFMAOACYP19A1 | |
| SCHEMBL3694617 | 0.81 | MAOB (1.00) | MAPTMAOBMIFMAOACYP19A1 | |
| SCHEMBL30977980 | 0.81 | MAOB (1.00) | MAPTMAOBMIFMAOACYP19A1 | |
| SCHEMBL30462577 | 0.81 | MAOB (1.00) | MAPTMAOBMIFMAOACYP19A1 | |
| SCHEMBL2981650 | 0.81 | MAOB (1.00) | MAPTMAOBMIFMAOACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165544-B1 | SUBSTITUTED 1,4-DIHYDROINDENO[1,2-C]PYRAZOLES AS INHIBITORS OF TYROSINE KINASE | KNOLL GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-1289525-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2003-03-12 | — | — | EP | disclosed |
| EP-1268437-A1 | INHIBITORS OF PROTEIN KINASES | Knoll GmbH (DE) | 2003-01-02 | — | — | EP | disclosed |
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |
| CN-1368970-A | Substituted 1,4-dihydroindeno [1,2-C] pyrazoles as inhibitors of tyrosine kinase | KNOLL GMBH (DE) | 2002-09-11 | — | — | CN | disclosed |
| WO-2002030908-A1 | INHIBITORS OF PROTEIN KINASES | KNOLL GMBH (DE) | 2002-04-18 | — | — | WO | disclosed |
| WO-2001087846-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |
| US-6297238-B1 | 3-ARYL PYRAZOLES WITH 4,5(3,4)-BICYCLIC RING FUSION WHICH ARE INHIBITORS OF PROTEIN KINASES PARTICULARLY TYROSINE KINASES AND SERINE/THREONINE KINASES | BASF AKTIENGESELLSCHAFT (DE) | 2001-10-02 | — | — | US | disclosed |
| EP-0084671-B1 | ANILINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN COMBATING UNDESIRED PLANT GROWTH, AND INTERMEDIATES FOR THEIR PREPARATION | BASF Aktiengesellschaft (DE) | 1986-03-05 | — | — | EP | disclosed |
| EP-0084671-A2 | Aniline derivatives, process for their preparation and their use in combating undesired plant growth, and intermediates for their preparation | BASF Aktiengesellschaft (DE) | 1983-08-03 | — | — | EP | disclosed |