Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | HPGD | P15428 | 1/20 | 0.79 |
| ▸ | MIF | P14174 | 3/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | STK17B | O94768 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701179 | 1.00 | MAPT (0.79) | MAPTALDH1A1LMNAHPGDMIF | |
| SCHEMBL8547623 | 0.88 | MAPT (1.00) | MAPTALDH1A1LMNAHPGDMIF | |
| SCHEMBL8547627 | 0.88 | MAPT (1.00) | MAPTALDH1A1LMNAHPGDMIF | |
| SCHEMBL7000852 | 0.85 | MAPT (0.78) | MAPTALDH1A1LMNAHPGDMIF | |
| SCHEMBL7000855 | 0.85 | MAPT (0.78) | MAPTALDH1A1LMNAHPGDMIF | |
| SCHEMBL31358690 | 0.79 | MAPT (0.58) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL2981650 | 0.78 | MAOB (1.00) | MAPTALDH1A1MIFMAOAMAOB | |
| SCHEMBL3694617 | 0.78 | MAOB (1.00) | MAPTALDH1A1MIFMAOAMAOB | |
| SCHEMBL30462577 | 0.78 | MAOB (1.00) | MAPTALDH1A1MIFMAOAMAOB | |
| SCHEMBL30977980 | 0.78 | MAOB (1.00) | MAPTALDH1A1MIFMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |