SCHEMBL7001130

SCHEMBL7001130

N[C@@H]1C[C@H]1c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 15/20 0.58
MAOB P27338 9/20 0.58
MAOA P21397 7/20 0.58
KCNH2 Q12809 3/20 0.48
RCOR1 Q9UKL0 3/20 0.48
KDM1B Q8NB78 1/20 0.48
CYP2C19 P33261 4/20 0.47
CYP2B6 P20813 3/20 0.47
CYP1A2 P05177 2/20 0.47
CYP2D6 P10635 2/20 0.47
CYP2C9 P11712 2/20 0.47
LMNA P02545 1/20 0.47
CYP3A4 P08684 1/20 0.47
HTR1A P08908 1/20 0.47
ADRA2A P08913 1/20 0.47
CYP2A6 P11509 1/20 0.47
SLC6A2 P23975 1/20 0.47
HTR2C P28335 1/20 0.47
ADRA1A P35348 1/20 0.47
DRD3 P35462 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7001127 1.00 KDM1A (0.58) KDM1AMAOBMAOAKCNH2RCOR1
SCHEMBL18998726 0.81 KDM1A (0.47) KDM1AMAOBMAOAKCNH2RCOR1
SCHEMBL18998470 0.81 KDM1A (0.47) KDM1AMAOBMAOAKCNH2RCOR1
SCHEMBL12875677 0.81 KDM1A (0.47) KDM1AMAOBMAOAKCNH2RCOR1
SCHEMBL12971945 0.81 KDM1A (0.63) KDM1AMAOBMAOAKCNH2RCOR1
SCHEMBL31187344 0.81 MAOA (0.64) KDM1AMAOBMAOARCOR1KDM1B
SCHEMBL4608227 0.79 KDM1A (0.40) KDM1AMAOBMAOARCOR1
Hydrochloric Acid SCHEMBL21491485 0.78 KDM1A (0.48) KDM1ARCOR1SLC6A2SLC6A3
SCHEMBL19004672 0.78 KDM1A (0.44) KDM1AMAOBMAOAKCNH2RCOR1
SCHEMBL25004743 0.75 KDM1A (0.43) KDM1AMAOBMAOARCOR1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1056749-B1 NOVEL TRIAZOLO(4,5-d)PYRIMIDINE COMPOUNDS ASTRAZENECA UK LTD (GB) 2003-02-19 EP disclosed
US-6369064-B1 MYOCARDIAL INFARCTION AND UNSTABLE ANGINA; P2T-RECEPTOR ANTAGONISTS; ANTITHROMBOTIC AGENTS; 7-(SUBSTITUTED AMINO) -5-(THIO)-3H-1,2,3-TRIAZOLO(4,5-D)PYRIMIDIN-3-YL) -CYCLOPENTANECARBOXAMIDES ASTRAZENECA AB (SE) 2002-04-09 US disclosed