Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000963 | 0.92 | BRAF (0.44) | BRAFPTGS2PTGS1BRD4 | |
| SCHEMBL6999308 | 0.91 | BRAF (0.42) | BRAFPTGS2PTGS1BRD4 | |
| SCHEMBL6998598 | 0.90 | PTGS2 (0.44) | BRAFPTGS2PTGS1BRD4PDE3B | |
| SCHEMBL6997339 | 0.88 | BRAF (0.41) | BRAFPTGS2PTGS1CYP3A4HSD11B1 | |
| SCHEMBL6997983 | 0.88 | PTGS2 (0.38) | BRAFPTGS2PTGS1BRD4CA12 | |
| SCHEMBL7002262 | 0.85 | PTGS2 (0.38) | BRAFPTGS2PTGS1BRD4CA12 | |
| SCHEMBL3232556 | 0.84 | PTGS2 (0.45) | BRAFPTGS2PTGS1BRD4 | |
| SCHEMBL6994546 | 0.84 | PTGS2 (0.40) | BRAFPTGS2PTGS1 | |
| SCHEMBL6996437 | 0.84 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL7002132 | 0.83 | BRAF (0.42) | BRAFPTGS2PTGS1BRD4PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |