Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 8/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.45 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700697 | 0.88 | DYRK1A (0.49) | DYRK1AHDAC1IRAK4MAPK10CDK2 | |
| SCHEMBL701046 | 0.87 | DYRK1A (0.60) | DYRK1AHDAC1IRAK4MAPK10CDK2 | |
| SCHEMBL700029 | 0.87 | HDAC1 (0.67) | DYRK1AHDAC1IRAK4MAPK10 | |
| SCHEMBL273685 | 0.78 | CDK2 (0.54) | CDK2MAPK8MAPK9CDK1CDK4 | |
| SCHEMBL7991714 | 0.77 | DYRK1A (0.52) | DYRK1AHDAC1IRAK4MAPK10CDK2 | |
| SCHEMBL699645 | 0.77 | CDK2 (0.67) | DYRK1AHDAC1IRAK4MAPK10CDK2 | |
| SCHEMBL7988056 | 0.77 | DYRK1A (0.49) | DYRK1AHDAC1IRAK4MAPK10CDK2 | |
| SCHEMBL699195 | 0.76 | HDAC1 (0.64) | DYRK1AHDAC1 | |
| SCHEMBL701954 | 0.75 | HDAC1 (0.68) | DYRK1AHDAC1IRAK4MAPK10 | |
| SCHEMBL658194 | 0.74 | HDAC1 (0.47) | DYRK1AHDAC1IRAK4MAPK10CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | claimed |
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-02-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC7 | DYRK1A 3146/4885HDAC1 1/4885IRAK4 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.