Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700179 | 0.87 | DYRK1A (0.54) | DYRK1AIRAK4MAPK10HDAC1MAPK8 | |
| SCHEMBL701954 | 0.86 | HDAC1 (0.68) | DYRK1AIRAK4MAPK10HDAC1 | |
| SCHEMBL700697 | 0.83 | DYRK1A (0.49) | DYRK1AIRAK4MAPK10HDAC1MAPK8 | |
| SCHEMBL699645 | 0.80 | CDK2 (0.67) | DYRK1AIRAK4MAPK10HDAC1MAPK8 | |
| SCHEMBL273046 | 0.77 | CDK2 (0.56) | MAPK8MAPK9CDK2CDK1CDK4 | |
| SCHEMBL658194 | 0.77 | HDAC1 (0.47) | DYRK1AIRAK4MAPK10HDAC1MAPK8 | |
| SCHEMBL700029 | 0.75 | HDAC1 (0.67) | DYRK1AIRAK4MAPK10HDAC1 | |
| SCHEMBL699041 | 0.73 | CDK2 (0.68) | IRAK4MAPK10HDAC1MAPK8MAPK9 | |
| SCHEMBL7991714 | 0.72 | DYRK1A (0.52) | DYRK1AIRAK4MAPK10HDAC1MAPK8 | |
| SCHEMBL1684774 | 0.71 | CDK2 (0.58) | DYRK1AHDAC1CDK2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | claimed |
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-02-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC7 | DYRK1A 3146/4885IRAK4 2350/4885MAPK10 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.