Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.57 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031974 | 0.92 | MAPT (0.67) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL37935 | 0.92 | MAPT (0.67) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL37936 | 0.92 | MAPT (0.67) | TDP1GLAHDAC3HDAC4HDAC1 | |
| Acetone SCHEMBL29037563 | 0.90 | TDP1 (0.67) | TDP1GLAHDAC3HDAC4HDAC1 | |
| Fluoride SCHEMBL28142752 | 0.90 | MAPT (0.64) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL27826046 | 0.90 | MAPT (0.64) | TDP1GLAHDAC3HDAC4HDAC1 | |
| Water SCHEMBL28081094 | 0.90 | MAPT (0.64) | TDP1GLAHDAC3HDAC4HDAC1 | |
| Trimethylammonium SCHEMBL27838937 | 0.88 | GLA (0.59) | TDP1GLAHDAC3HDAC4HDAC1 | |
| Chloroform SCHEMBL28195041 | 0.86 | MAPT (0.59) | TDP1GLAHDAC3HDAC4HDAC1 | |
| Chloroform SCHEMBL28195040 | 0.86 | MAPT (0.59) | TDP1GLAHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
| US-6251910-B1 | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists | ASTRAZENECA UK LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |