Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 13/20 | 0.69 |
| ▸ | NFE2L2 | Q16236 | 13/20 | 0.69 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003143 | 0.85 | KEAP1 (0.71) | KEAP1NFE2L2HCRTR2MAPTALDH1A1 | |
| SCHEMBL1629060 | 0.82 | KEAP1 (1.00) | KEAP1NFE2L2 | |
| SCHEMBL5622498 | 0.81 | KEAP1 (0.68) | KEAP1NFE2L2MAPTCNR1CNR2 | |
| SCHEMBL1039041 | 0.81 | HCRTR2 (0.77) | KEAP1NFE2L2HCRTR2MAPTALDH1A1 | |
| SCHEMBL7000752 | 0.80 | KEAP1 (0.66) | KEAP1NFE2L2MAPTCNR1CNR2 | |
| SCHEMBL7003241 | 0.79 | KEAP1 (0.61) | KEAP1NFE2L2MAPTCNR1CNR2 | |
| SCHEMBL7003318 | 0.78 | KEAP1 (0.72) | KEAP1NFE2L2MAPTCYP3A4CYP2C9 | |
| SCHEMBL12533188 | 0.78 | KEAP1 (0.76) | KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL7182031 | 0.78 | ESR1 (0.79) | KEAP1NFE2L2MAPTCNR1CNR2 | |
| SCHEMBL7004297 | 0.77 | KEAP1 (0.89) | KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154992-A4 | N-SUBSTITUTED ARYLSULFONYLAMINO HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF C-PROTEINASE AND FOR TREATING OR PREVENTING DISORDERS RELATED TO UNREGULATED COLLAGEN PRODUCTION | FIBROGEN INC (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1154992-A1 | N-SUBSTITUTED ARYLSULFONYLAMINO HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF C-PROTEINASE AND FOR TREATING OR PREVENTING DISORDERS RELATED TO UNREGULATED COLLAGEN PRODUCTION | FIBROGEN, INC. (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050390-A1 | N-SUBSTITUTED ARYLSULFONYLAMINO HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF C-PROTEINASE AND FOR TREATING OR PREVENTING DISORDERS RELATED TO UNREGULATED COLLAGEN PRODUCTION | FIBROGEN, INC. (US) | 2000-08-31 | — | — | WO | disclosed |