Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.73 |
| ▸ | LCK | P06239 | 16/20 | 0.73 |
| ▸ | TEK | Q02763 | 16/20 | 0.73 |
| ▸ | KDR | P35968 | 7/20 | 0.70 |
| ▸ | BTK | Q06187 | 3/20 | 0.68 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.58 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.58 |
| ▸ | IGF1R | P08069 | 3/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.58 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.58 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.57 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431750 | 0.94 | SRC (0.72) | SRCLCKTEKKDRBTK | |
| SCHEMBL6431748 | 0.94 | SRC (0.72) | SRCLCKTEKKDRBTK | |
| SCHEMBL6431693 | 0.93 | SRC (0.75) | SRCLCKTEKKDRBTK | |
| SCHEMBL6431699 | 0.93 | SRC (0.75) | SRCLCKTEKKDRBTK | |
| SCHEMBL6433819 | 0.90 | LCK (0.66) | SRCLCKTEKKDRBTK | |
| SCHEMBL6433820 | 0.90 | LCK (0.66) | SRCLCKTEKKDRBTK | |
| SCHEMBL5801412 | 0.89 | LCK (0.65) | SRCLCKTEKKDRBTK | |
| SCHEMBL6884880 | 0.89 | LCK (0.65) | SRCLCKTEKKDRBTK | |
| SCHEMBL5801411 | 0.89 | LCK (0.65) | SRCLCKTEKKDRBTK | |
| Acetic Acid SCHEMBL6430207 | 0.89 | SRC (0.65) | SRCLCKTEKKDRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |