Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.65 |
| ▸ | SRC | P12931 | 12/20 | 0.65 |
| ▸ | TEK | Q02763 | 12/20 | 0.65 |
| ▸ | KDR | P35968 | 6/20 | 0.63 |
| ▸ | BTK | Q06187 | 5/20 | 0.60 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.59 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.58 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 7/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801412 | 1.00 | LCK (0.65) | LCKSRCTEKKDRBTK | |
| SCHEMBL6884880 | 1.00 | LCK (0.65) | LCKSRCTEKKDRBTK | |
| Acetic Acid SCHEMBL6431923 | 0.99 | LCK (0.64) | LCKSRCTEKKDRBTK | |
| Acetic Acid SCHEMBL6431918 | 0.99 | LCK (0.64) | LCKSRCTEKKDRBTK | |
| SCHEMBL7001945 | 0.89 | SRC (0.73) | LCKSRCTEKKDRBTK | |
| SCHEMBL6431748 | 0.89 | SRC (0.72) | LCKSRCTEKKDRBTK | |
| SCHEMBL6431750 | 0.89 | SRC (0.72) | LCKSRCTEKKDRBTK | |
| SCHEMBL6431693 | 0.87 | SRC (0.75) | LCKSRCTEKKDRBTK | |
| SCHEMBL6431699 | 0.87 | SRC (0.75) | LCKSRCTEKKDRBTK | |
| SCHEMBL6623451 | 0.87 | LCK (0.77) | LCKSRCTEKKDRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |