Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.92 |
| ▸ | POLB | P06746 | 3/20 | 0.76 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 5/20 | 0.73 |
| ▸ | MEN1 | O00255 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | XBP1 | P17861 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5642288 | 1.00 | DPP4 (0.92) | DPP4POLBSIRT5TSHRMEN1 | |
| SCHEMBL555020 | 0.96 | DPP4 (1.00) | DPP4POLBSIRT5TSHRMEN1 | |
| SCHEMBL5641788 | 0.92 | DPP4 (0.78) | DPP4POLBSIRT5TSHRMEN1 | |
| SCHEMBL5639564 | 0.92 | DPP4 (0.77) | DPP4POLBSIRT5TSHRMEN1 | |
| SCHEMBL5638147 | 0.88 | ALDH1A1 (0.73) | DPP4POLBSIRT5TSHRMEN1 | |
| SCHEMBL7562242 | 0.88 | DPP4 (0.84) | DPP4POLBSIRT5TSHRMEN1 | |
| SCHEMBL5640606 | 0.87 | DPP4 (0.83) | DPP4POLBSIRT5TSHRMEN1 | |
| SCHEMBL5642757 | 0.87 | DPP4 (0.69) | DPP4POLBSIRT5TSHRMEN1 | |
| SCHEMBL5075029 | 0.86 | POLB (0.84) | DPP4POLBSIRT5TSHRMEN1 | |
| SCHEMBL5643517 | 0.86 | L3MBTL1 (0.75) | DPP4POLBSIRT5TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301187-A2 | HETEROCYCLIC COMPOUNDS, WHICH ARE INHIBITORS OF THE ENZYME DPP-IV | NOVO NORDISK A/S (DK) | 2003-04-16 | — | — | EP | claimed |
| WO-2002002560-A2 | PURINE-2,6-DIONES WHICH ARE INHIBITORS OF THE ENZYME DIPEPTIDYL PEPTIDASE IV (DPP-IV) | NOVO NORDISK A/S (DK) | 2002-01-10 | — | — | WO | claimed |