Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | DHFR | P00374 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002362 | 1.00 | MAPT (0.39) | MAPTDHFRALDH1A1HSD17B10HPGD | |
| SCHEMBL6994277 | 0.88 | MAPT (0.40) | MAPTDHFRALDH1A1LMNATP53 | |
| SCHEMBL6994283 | 0.88 | MAPT (0.40) | MAPTDHFRALDH1A1LMNATP53 | |
| SCHEMBL6850124 | 0.84 | MAPT (0.46) | MAPTALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL6850099 | 0.84 | MAPT (0.40) | MAPTDHFRHSD17B10NPSR1LMNA | |
| SCHEMBL6850102 | 0.84 | MAPT (0.40) | MAPTDHFRHSD17B10NPSR1LMNA | |
| SCHEMBL6854856 | 0.83 | MAPT (0.40) | MAPTDHFRHSD17B10NPSR1LMNA | |
| SCHEMBL6854862 | 0.83 | MAPT (0.40) | MAPTDHFRHSD17B10NPSR1LMNA | |
| SCHEMBL6854150 | 0.82 | DHFR (0.42) | MAPTDHFRALDH1A1HPGDTP53 | |
| SCHEMBL6854144 | 0.82 | DHFR (0.42) | MAPTDHFRALDH1A1HPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | claimed |
| WO-2000066584-B1 | 1-AMINO TRIAZOLO¢4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2001-02-15 | — | — | WO | claimed |