Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 19/20 | 0.49 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000993 | 0.83 | F10 (0.62) | F10 | |
| SCHEMBL6702010 | 0.83 | F10 (0.72) | KCNH2F10KLK1 | |
| SCHEMBL6698016 | 0.80 | KCNH2 (0.83) | KCNH2F10KLK1 | |
| SCHEMBL6697387 | 0.80 | KCNH2 (0.67) | KCNH2F10KLK1 | |
| SCHEMBL6698024 | 0.79 | KCNH2 (0.61) | KCNH2F10KLK1 | |
| SCHEMBL6697976 | 0.78 | F10 (0.71) | KCNH2F10 | |
| SCHEMBL6703461 | 0.78 | F10 (0.71) | KCNH2F10 | |
| SCHEMBL6695164 | 0.78 | F10 (0.71) | KCNH2F10 | |
| SCHEMBL6696428 | 0.77 | KCNH2 (0.71) | KCNH2F10 | |
| SCHEMBL6697977 | 0.77 | KCNH2 (0.55) | KCNH2F10KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322643-A1 | PIPERAZIN-2-ONE AMIDES AS INHIBITORS OF FACTOR XA | Millennium Pharmaceuticals, Inc. (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002026734-A1 | PIPERAZIN-2-ONE AMIDES AS INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2002-04-04 | — | — | WO | disclosed |