SCHEMBL7002680

SCHEMBL7002680

COc1ccc(Nc2ccccc2Cl)c(C)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.64
FABP3 P05413 1/20 0.49
FABP4 P15090 1/20 0.49
RAB9A P51151 1/20 0.49
ADRA2A P08913 1/20 0.49
ADRA2C P18825 1/20 0.49
ADRA1D P25100 1/20 0.49
ADRA1A P35348 1/20 0.49
ADRA1B P35368 1/20 0.49
TOP1 P11387 2/20 0.48
MAPK14 Q16539 1/20 0.46
POLB P06746 2/20 0.46
MAPT P10636 1/20 0.46
APEX1 P27695 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
P2RX7 Q99572 3/20 0.45
CLK1 P49759 2/20 0.45
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
ALDH1A1 P00352 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10639862 0.86 GAA (0.72) GAARAB9AADRA2AADRA2CADRA1D
SCHEMBL10784705 0.84 GAA (0.57) GAAFABP3FABP4TOP1POLB
SCHEMBL6439831 0.81 GAA (0.64) GAARAB9AADRA2AADRA2CADRA1D
SCHEMBL4008687 0.81 MEN1 (0.55) GAAFABP3FABP4TOP1MAPT
SCHEMBL7001777 0.81 RAB9A (0.68) GAARAB9AADRA2AADRA2CADRA1D
SCHEMBL6440701 0.80 TOP1 (0.63) FABP3FABP4RAB9ATOP1POLB
SCHEMBL9372000 0.80 FABP3 (0.55) GAAFABP3FABP4TOP1MAPK14
Hydrochloric Acid SCHEMBL6438214 0.79 MAPT (0.62) GAARAB9AADRA2AADRA2CADRA1D
SCHEMBL10640051 0.79 GAA (0.61) GAARAB9AADRA2AADRA2CADRA1D
SCHEMBL10851025 0.78 GAA (0.60) GAARAB9AADRA2AADRA2CADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6635602-B1 Heat sensitive and pressure sensitive recording material; synthesised directly by the reaction of two derivatives of amino phenols, phthalic anhydrides, keto acids and/or diphenylamines with a phenol derivative CIBA SPECIALTY CHEMICALS CORPORATION 2003-10-21 US disclosed
US-6566302-B1 For use in heat sensitive and pressure sensitive recording materials CIBA SPECIALTY CHEMICALS CORPORATION 2003-05-20 US disclosed
EP-1107972-B1 PREPARATION PROCESS FOR MANUFACTURE AND PURIFICATION OF MIXTURES OF FLUORAN COMPOUNDS AND RECORDING MATERIAL COMPRISING SAID MIXTURES OF FLUORAN CIBA SC HOLDING AG (CH) 2003-01-02 EP disclosed
EP-1115579-B1 MONOPHASE SOLID SOLUTIONS COMPRISING A PLURALITY OF COLOUR FORMER COMPOUNDS AND PROCESS FOR THEIR PREPARATION CIBA SC HOLDING AG (CH) 2002-11-20 EP disclosed
EP-1115579-A1 MONOPHASE SOLID SOLUTIONS COMPRISING A PLURALITY OF COLOUR FORMER COMPOUNDS AND PROCESS FOR THEIR PREPARATION Ciba SC Holding AG (CH) 2001-07-18 EP disclosed
WO-2000026037-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-05-11 WO disclosed
WO-2000012318-A1 MONOPHASE SOLID SOLUTIONS COMPRISING A PLURALITY OF COLOUR FORMER COMPOUNDS AND PROCESS FOR THEIR PREPARATION CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-03-09 WO disclosed