SCHEMBL700275

SCHEMBL700275

Cc1cc(C)cc(Oc2ccc(C#N)cc2S(=O)(=O)N2CCNCC2)c1

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.52
ALDH1A1 P00352 1/20 0.47
TBXA2R P21731 11/20 0.45
USP2 O75604 2/20 0.42
GAA P10253 1/20 0.42
BRD4 O60885 1/20 0.42
BRD2 P25440 1/20 0.42
BRD3 Q15059 1/20 0.42
TSHR P16473 2/20 0.41
KDM4E B2RXH2 1/20 0.41
PKM P14618 1/20 0.41
HTR6 P50406 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2822890 0.99 KMT2A (0.51) KMT2AALDH1A1TBXA2RUSP2GAA
SCHEMBL13108358 0.89 TBXA2R (0.48) KMT2ATBXA2RUSP2GAATSHR
SCHEMBL693683 0.89 TBXA2R (0.45) KMT2ATBXA2RUSP2GAATSHR
SCHEMBL693479 0.87 TBXA2R (0.48) KMT2AALDH1A1TBXA2RUSP2GAA
SCHEMBL13108120 0.87 TBXA2R (0.44) KMT2ATBXA2RUSP2GAATSHR
SCHEMBL2824037 0.86 KMT2A (0.49) KMT2AALDH1A1TBXA2RUSP2BRD4
SCHEMBL1279808 0.86 MAPK1 (0.46) KMT2AALDH1A1TBXA2RUSP2GAA
Bromide SCHEMBL1279110 0.85 MAPK1 (0.45) KMT2AALDH1A1TBXA2RUSP2GAA
Hydrochloric Acid SCHEMBL1279664 0.85 MAPK1 (0.45) KMT2AALDH1A1TBXA2RUSP2GAA
SCHEMBL12693469 0.85 TBXA2R (0.47) KMT2AALDH1A1TBXA2RUSP2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7700586-B2 Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders AXIKIN PHARMACEUTICALS, INC. (US) 2010-04-20 US claimed
EP-1461038-B9 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS ACTIMIS PHARMACEUTICALS INC (US) 2009-09-23 EP claimed
EP-1849469-A1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS Actimis Pharmaceuticals, Inc., (US) 2007-10-31 EP claimed
EP-1461038-B1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS ACTIMIS PHARMACEUTICALS INC (US) 2007-08-01 EP claimed
US-20050070582-A1 Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders BAYER HEALTHCARE AG (DE) 2005-03-31 US claimed
EP-1461038-A1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS Bayer HealthCare AG (DE) 2004-09-29 EP claimed
WO-2003022277-A1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS BAYER HEALTHCARE AG (DE) 2003-03-20 WO claimed
EP-2502921-B1 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS INC (US) 2015-05-20 EP disclosed
EP-2502921-B1 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS INC (US) 2015-05-20 EP disclosed
US-8658642-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2014-02-25 US disclosed
US-8658642-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2014-02-25 US disclosed
US-8658642-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2014-02-25 US disclosed
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-08-22 US disclosed
EP-1461038-B9 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS ACTIMIS PHARMACEUTICALS INC (US) 2009-09-23 EP disclosed
EP-1849469-A1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS Actimis Pharmaceuticals, Inc., (US) 2007-10-31 EP disclosed
EP-1461038-B1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS ACTIMIS PHARMACEUTICALS INC (US) 2007-08-01 EP disclosed
EP-1461038-B1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS ACTIMIS PHARMACEUTICALS INC (US) 2007-08-01 EP disclosed
US-20050070582-A1 Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders BAYER HEALTHCARE AG (DE) 2005-03-31 US disclosed
EP-1461038-A1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS Bayer HealthCare AG (DE) 2004-09-29 EP disclosed
WO-2003022277-A1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS BAYER HEALTHCARE AG (DE) 2003-03-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050070582-A1 Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders CCR3, CCR1, CCR2 KMT2A 2753/4885ALDH1A1 2416/4885TBXA2R 1120/4885
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 KMT2A 2688/4885ALDH1A1 2454/4885TBXA2R 2704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.