Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 3/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994870 | 0.88 | TDP1 (0.54) | TDP1POLBMCL1MAPTALOX15 | |
| SCHEMBL21895670 | 0.81 | MCL1 (0.38) | TDP1POLBAPEX1MCL1MAPT | |
| SCHEMBL6995042 | 0.80 | HSD11B1 (0.47) | TDP1POLBAPEX1CES2CES1 | |
| SCHEMBL3321763 | 0.76 | KMT2A (0.49) | TDP1POLBALDH1A1 | |
| SCHEMBL21340413 | 0.75 | POLB (0.50) | POLBMCL1MAPTALOX15HTT | |
| SCHEMBL22570568 | 0.73 | MCL1 (0.52) | TDP1POLBMCL1MAPTALOX15 | |
| SCHEMBL13400656 | 0.73 | MAPT (0.48) | TDP1POLBMCL1MAPTALOX15 | |
| SCHEMBL18428493 | 0.73 | HTR2A (0.56) | MCL1ALDH1A1HTR2ACPB1 | |
| SCHEMBL324342 | 0.73 | HTR2A (0.56) | MCL1ALDH1A1HTR2ACPB1 | |
| Acetic Acid SCHEMBL2762930 | 0.72 | HTR2A (0.51) | MCL1ALDH1A1HTR2ACPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921119-B1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-07-02 | — | — | EP | disclosed |
| US-6114360-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-09-05 | — | — | US | disclosed |
| US-6063804-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0921119-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-09 | — | — | EP | disclosed |