Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | ILK | Q13418 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28165622 | 0.82 | ALPL (0.33) | — | |
| SCHEMBL21775709 | 0.81 | IDO1 (0.32) | NOS1NOS2NOS3MAPT | |
| SCHEMBL29711475 | 0.79 | PDPK1 (0.31) | NPC1MAPTHPGDSMN1; SMN2MEN1 | |
| SCHEMBL30375058 | 0.79 | IDO1 (0.49) | ALOX5APFEN1GAAKDM4ENPC1 | |
| SCHEMBL2083395 | 0.79 | IDO1 (0.49) | ALOX5APFEN1GAAKDM4ENPC1 | |
| SCHEMBL2089783 | 0.78 | GAA (0.41) | NOS1NOS2GAANOS3KDM4E | |
| SCHEMBL3340666 | 0.77 | CHEK1 (0.43) | GAAHSD17B10MAPTHPGDSMN1; SMN2 | |
| SCHEMBL168536 | 0.74 | MAPT (0.54) | KDM4ENPC1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL15656631 | 0.72 | NOTUM (0.44) | GAANPC1HSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL244618 | 0.71 | ALPL (0.54) | KDM4ENPC1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566363-B2 | 5-amino-3-substituted-pyrazolo(4,5-d)thiazole compounds that mediate and/or inhibit the activity of cyclin-dependent kinases, useful for treating cancer, angiogenesis and cellular proliferation | AGOURON PHARMACEUTICALS, INC. | 2003-05-20 | — | — | US | disclosed |
| EP-1307462-A2 | PYRAZOLE-THIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND METHODS OF THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASES | Agouron Pharmaceuticals, Inc. (US) | 2003-05-07 | — | — | EP | disclosed |
| US-20020049215-A1 | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases | AGOURON PHARMACEUTICALS, INC. | 2002-04-25 | — | — | US | disclosed |
| WO-2002012250-A2 | PYRAZOLE-THIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND METHODS OF THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049215-A1 | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases | CDK4, CCNK, CDK2 | ALOX5AP 1956/4885FEN1 3341/4885NOS1 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.