Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HCN1 | O60741 | 3/20 | 0.37 |
| ▸ | HCN4 | Q9Y3Q4 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003806 | 0.89 | KMT2A (0.41) | LMNARAB9APOLBMEN1KMT2A | |
| SCHEMBL7004895 | 0.88 | DUSP3 (0.34) | LMNARAB9APOLBMEN1KMT2A | |
| SCHEMBL7006925 | 0.76 | KCNJ1 (0.37) | MAPK1KCNH2TSHRHSD17B10 | |
| SCHEMBL5875796 | 0.75 | MEN1 (0.60) | MAPK1LMNARAB9APOLBHTT | |
| SCHEMBL12380564 | 0.75 | KDM4E (0.52) | LMNAADRB2ADRB1ADRB3ADRA1D | |
| SCHEMBL7860492 | 0.68 | MAPK1 (0.51) | MAPK1LMNARAB9AADRB2ADRB1 | |
| SCHEMBL15487159 | 0.68 | MAPT (0.53) | MAPK1LMNARAB9AADRB2ADRB1 | |
| SCHEMBL28045267 | 0.68 | KDM4E (0.57) | MAPK1LMNARAB9AHTTMEN1 | |
| SCHEMBL31565683 | 0.67 | MAPK1 (0.50) | MAPK1LMNARAB9AADRB2ADRB1 | |
| SCHEMBL11627993 | 0.67 | MEN1 (0.53) | MAPK1LMNARAB9AHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292586-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIMIDINONES | Pfizer Limited (GB) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001098284-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIMIDINONES | PFIZER LIMITED (GB) | 2001-12-27 | — | — | WO | disclosed |