Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HCN1 | O60741 | 3/20 | 0.33 |
| ▸ | HCN4 | Q9Y3Q4 | 3/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003402 | 0.88 | MAPK1 (0.41) | POLBKMT2AMEN1HCN1HCN4 | |
| SCHEMBL7003806 | 0.85 | KMT2A (0.41) | DUSP3PTPN5PTPN11POLBALDH1A1 | |
| SCHEMBL26507815 | 0.77 | PRSS1 (0.38) | ALDH1A1KMT2AF2F10PRSS1 | |
| SCHEMBL7006925 | 0.76 | KCNJ1 (0.37) | DUSP3PTPN5PTPN11ALDH1A1HSD17B10 | |
| SCHEMBL12380569 | 0.75 | KDM4E (0.49) | ALDH1A1KMT2AMEN1HSD17B10HPGD | |
| SCHEMBL5875625 | 0.74 | TSHR (0.57) | POLBALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL24508171 | 0.68 | KDM4E (0.53) | POLBALDH1A1KMT2AMEN1F2 | |
| SCHEMBL17040591 | 0.67 | TSHR (0.49) | KMT2AMEN1F2F10PRSS1 | |
| SCHEMBL12380550 | 0.66 | MAPK1 (0.50) | ALDH1A1KMT2AMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL2571089 | 0.66 | PDE5A (0.53) | KMT2AMEN1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292586-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIMIDINONES | Pfizer Limited (GB) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001098284-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIMIDINONES | PFIZER LIMITED (GB) | 2001-12-27 | — | — | WO | disclosed |