Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996208 | 0.90 | PDE5A (0.47) | PDE5AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7001362 | 0.88 | KMT2A (0.48) | PDE5AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6999063 | 0.86 | KMT2A (0.48) | PDE5AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7003070 | 0.86 | PDE5A (0.48) | PDE5AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6996654 | 0.84 | KMT2A (0.46) | PDE5AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7003426 | 0.84 | KMT2A (0.46) | PDE5AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7006028 | 0.83 | KMT2A (0.45) | PDE5AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7005525 | 0.81 | KMT2A (0.48) | PDE5AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7668666 | 0.79 | POLB (0.47) | PDE5AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7000539 | 0.73 | ADORA1 (0.54) | KMT2AADORA3LMNATSHRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | disclosed |
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1087973-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | Boehringer Ingelheim Pharma KG (DE) | 2001-04-04 | — | — | EP | disclosed |
| WO-2000012511-A1 | IMIDAZOTRIAZOLOPYRIMIDINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-09 | — | — | WO | disclosed |
| WO-1999065912-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-12-23 | — | — | WO | disclosed |