Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 6/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001362 | 0.88 | KMT2A (0.48) | KMT2ALMNANPSR1PDE5AADORA3 | |
| SCHEMBL6999063 | 0.88 | KMT2A (0.48) | KMT2ALMNANPSR1PDE5AADORA3 | |
| SCHEMBL7003070 | 0.88 | PDE5A (0.48) | KMT2ALMNANPSR1PDE5AADORA3 | |
| SCHEMBL7668666 | 0.87 | POLB (0.47) | KMT2ALMNANPSR1PDE5AADORA3 | |
| SCHEMBL6996208 | 0.86 | PDE5A (0.47) | KMT2ALMNANPSR1PDE5AADORA3 | |
| SCHEMBL6996654 | 0.86 | KMT2A (0.46) | KMT2ALMNANPSR1PDE5AADORA3 | |
| SCHEMBL7003426 | 0.85 | KMT2A (0.46) | KMT2ALMNANPSR1PDE5AADORA3 | |
| SCHEMBL7003453 | 0.83 | PDE5A (0.45) | KMT2ALMNANPSR1PDE5AADORA3 | |
| SCHEMBL7005525 | 0.82 | KMT2A (0.48) | KMT2ALMNANPSR1PDE5AADORA3 | |
| SCHEMBL7661646 | 0.78 | TLR7 (0.41) | KMT2ALMNANPSR1L3MBTL1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | disclosed |
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |