Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27470034 | 0.85 | TSHR (0.43) | TSHRIDO1AGXTMAOB | |
| SCHEMBL8752385 | 0.85 | TSHR (0.48) | TSHRIDO1AGXTCA1CA2 | |
| Water SCHEMBL10609439 | 0.82 | TSHR (0.94) | TSHRIDO1AGXTCA1CA2 | |
| Water SCHEMBL15535487 | 0.82 | TSHR (0.94) | TSHRIDO1AGXTCA1CA2 | |
| SCHEMBL973837 | 0.82 | TSHR (0.38) | TSHR | |
| SCHEMBL27455971 | 0.81 | IDO1 (0.44) | TSHRIDO1KDM4EMAOB | |
| SCHEMBL6995199 | 0.80 | TSHR (0.71) | TSHRIDO1AGXTCA1CA2 | |
| SCHEMBL919605 | 0.80 | MAOB (0.50) | CA1CA2CA9CA7MAOB | |
| SCHEMBL27380 | 0.79 | TSHR (1.00) | TSHRIDO1AGXTCA1CA2 | |
| SCHEMBL5311581 | 0.79 | TSHR (1.00) | TSHRIDO1AGXTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1131202-C | Calcium receptor-active compounds | KIRIN BREWERY (JP) | 2003-12-17 | — | — | CN | disclosed |
| EP-1069126-B1 | TRIAZOLOPURINE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE DERIVATIVES, ADENOSINE A3 RECEPTOR COMPATIBILIZING AGENT, AND ASTHMATIC REMEDY | OTSUKA PHARMA CO LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-6288070-B1 | Triazolopurine derivatives, medicinal composition containing the derivatives, adenosine A3 receptor compatibilizing agent, and asthmatic remedy | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-09-11 | — | — | US | disclosed |
| EP-1069126-A1 | TRIAZOLOPURINE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE DERIVATIVES, ADENOSINE A3 RECEPTOR COMPATIBILIZING AGENT, AND ASTHMATIC REMEDY | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-01-17 | — | — | EP | disclosed |
| CN-1225083-A | Calcium receptor-active compounds | KIRIN BREWERY (JP) | 1999-08-04 | — | — | CN | disclosed |
| CN-1034569-C | ET (ENDOTHELIN) receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1997-04-16 | — | — | CN | disclosed |
| CN-1073161-A | ET (ENDOTHELIN) receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-06-16 | — | — | CN | disclosed |
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |