Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999969 | 0.91 | PTGS2 (0.55) | PTGS2PTGS1BRAF | |
| SCHEMBL7001135 | 0.90 | PTGS2 (0.39) | PTGS2PTGS1CA4BRAFCA1 | |
| SCHEMBL7001723 | 0.89 | PTGS2 (0.48) | PTGS2PTGS1CA4BRAFCA1 | |
| SCHEMBL7001112 | 0.89 | CA1 (0.43) | PTGS2PTGS1CA4CA1CA2 | |
| SCHEMBL7001070 | 0.88 | PTGS2 (0.41) | PTGS2PTGS1CA4CA1CA2 | |
| SCHEMBL7003146 | 0.88 | PTGS2 (0.42) | PTGS2PTGS1CA4CA1CA2 | |
| Polmacoxib SCHEMBL3233093 | 0.85 | PTGS2 (0.55) | PTGS2PTGS1CA1CA2CA9 | |
| Polmacoxib SCHEMBL29351757 | 0.85 | PTGS2 (0.55) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL7002269 | 0.84 | BRAF (0.41) | PTGS2PTGS1CA4BRAFCA1 | |
| SCHEMBL6997219 | 0.83 | CA1 (0.41) | PTGS2PTGS1CA4BRAFCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |