Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30721937 | 0.88 | MAPT (0.67) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL2063456 | 0.88 | MAPT (0.67) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL5704650 | 0.86 | CYP19A1 (0.63) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL25289864 | 0.85 | MAPT (0.58) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL1157681 | 0.85 | CYP19A1 (0.62) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL20258209 | 0.84 | MAPT (0.61) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| Bicarbonate SCHEMBL5500204 | 0.84 | CYP19A1 (0.63) | MAPTSMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL15814707 | 0.84 | MAPT (0.62) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL29178944 | 0.84 | MEN1 (0.52) | MAPTMEN1KMT2ACYP19A1CYP11B1 | |
| SCHEMBL5929724 | 0.83 | MAPT (0.67) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |