Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431028 | 0.85 | MAPT (0.59) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 | |
| SCHEMBL5704650 | 0.85 | CYP19A1 (0.63) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 | |
| SCHEMBL20258221 | 0.84 | MAPK1 (0.55) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 | |
| SCHEMBL7004393 | 0.84 | MAPT (0.56) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 | |
| SCHEMBL1157681 | 0.84 | CYP19A1 (0.62) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 | |
| SCHEMBL21295374 | 0.84 | MAPT (0.52) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 | |
| SCHEMBL30744023 | 0.84 | MAPT (0.52) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 | |
| SCHEMBL15967944 | 0.83 | MAPT (0.55) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 | |
| SCHEMBL10801307 | 0.83 | NPC1 (0.57) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 | |
| SCHEMBL7416033 | 0.82 | CYP19A1 (0.59) | MAPTSMN1; SMN2HPGDCYP2D6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000452-B1 | Quinolone-based compounds, formulations, and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2018-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000452-B1 | Quinolone-based compounds, formulations, and uses thereof | RECQL, NQO1, NQO2 | MAPT 1177/4885SMN1; SMN2 3435/4885HPGD 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.