Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 16/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004661 | 0.91 | F10 (0.46) | F10 | |
| SCHEMBL6694660 | 0.84 | F10 (0.64) | F10 | |
| SCHEMBL6694664 | 0.83 | F10 (0.46) | F10ALDH1A1HTTCYP3A4GAA | |
| SCHEMBL6695833 | 0.81 | F10 (0.64) | F10ALDH1A1HTT | |
| SCHEMBL6695837 | 0.81 | F10 (0.47) | F10ALDH1A1HTTCYP3A4GAA | |
| SCHEMBL6698165 | 0.81 | F10 (0.63) | F10ALDH1A1HTT | |
| SCHEMBL6997757 | 0.80 | F10 (0.66) | F10 | |
| SCHEMBL6698819 | 0.74 | F10 (0.68) | F10 | |
| SCHEMBL7000993 | 0.74 | F10 (0.62) | F10 | |
| SCHEMBL6698826 | 0.73 | F10 (0.48) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322643-A1 | PIPERAZIN-2-ONE AMIDES AS INHIBITORS OF FACTOR XA | Millennium Pharmaceuticals, Inc. (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002026734-A1 | PIPERAZIN-2-ONE AMIDES AS INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2002-04-04 | — | — | WO | disclosed |