Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALPL | P05186 | 1/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | ALPG | P10696 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008510 | 0.87 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7007695 | 0.82 | MAPT (0.54) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL16319317 | 0.78 | KMT2A (0.76) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7008830 | 0.77 | KDM4E (0.57) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7005593 | 0.77 | MAPT (0.63) | MAPTMAOBHTTHPGDCYP1A2 | |
| SCHEMBL1524274 | 0.76 | EGFR (0.72) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1524276 | 0.76 | EGFR (0.72) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL22624945 | 0.76 | KMT2A (1.00) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7012190 | 0.76 | MAPT (0.56) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL29857561 | 0.75 | MAPT (0.80) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103554-B9 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-12-17 | — | — | EP | disclosed |
| US-6548515-B1 | Use as anticancer agents | LES LABORATORIES SERVIER (FR) | 2003-04-15 | — | — | US | disclosed |
| EP-1103554-B1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-12 | — | — | EP | disclosed |
| EP-1103554-A1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-05-30 | — | — | EP | disclosed |