Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.55 |
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012190 | 0.83 | MAPT (0.56) | MAPTHTTLMNAHPGDMAOB | |
| SCHEMBL7008510 | 0.80 | MAPT (0.71) | MAPTHTTLMNAHPGDDYRK1A | |
| SCHEMBL13355216 | 0.79 | HPGD (0.50) | MAPTHTTLMNAHPGDMAOB | |
| SCHEMBL2442644 | 0.79 | HPGD (0.50) | MAPTHTTLMNAHPGDMAOB | |
| SCHEMBL2442647 | 0.79 | HPGD (0.50) | MAPTHTTLMNAHPGDMAOB | |
| SCHEMBL7008833 | 0.78 | MAPT (0.55) | MAPTHTTLMNAHPGDMAOB | |
| SCHEMBL9794694 | 0.78 | MAPK1 (0.71) | MAPTHTTLMNAHPGDMAOB | |
| SCHEMBL7005334 | 0.77 | ALDH1A1 (0.58) | MAPTLMNAHPGDMETAP1MAOB | |
| SCHEMBL7004431 | 0.77 | MAPT (0.61) | MAPTHTTLMNAHPGDMAOB | |
| SCHEMBL7008830 | 0.75 | KDM4E (0.57) | MAPTHTTLMNAHPGDMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103554-B9 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-12-17 | — | — | EP | disclosed |
| US-6548515-B1 | Use as anticancer agents | LES LABORATORIES SERVIER (FR) | 2003-04-15 | — | — | US | disclosed |
| EP-1103554-B1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-12 | — | — | EP | disclosed |
| EP-1103554-A1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-05-30 | — | — | EP | disclosed |