Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 9/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.38 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995002 | 0.87 | CCR1 (0.44) | CCR1FPR3GPR65GPR35PTGDR2 | |
| SCHEMBL7001642 | 0.85 | GRM2 (0.41) | PTGER4PTGER2CCR1FPR3GPR65 | |
| SCHEMBL7004496 | 0.84 | CCR1 (0.41) | PTGER4PTGER2CCR1FPR3GPR65 | |
| SCHEMBL6996220 | 0.83 | CCR1 (0.43) | CCR1FPR3GPR65GPR35HTR4 | |
| SCHEMBL7002094 | 0.81 | CCR1 (0.47) | CCR1FPR3GPR65GPR35S1PR5 | |
| SCHEMBL6999918 | 0.80 | CCR1 (0.40) | CCR1FPR3GPR65GPR35PTGDR2 | |
| SCHEMBL6999003 | 0.79 | CCR1 (0.41) | CCR1FPR3GPR65GPR35S1PR5 | |
| SCHEMBL7002872 | 0.76 | CCR1 (0.51) | CCR1FPR3GPR65GPR35HTR4 | |
| SCHEMBL6999933 | 0.76 | MEN1 (0.37) | PTGER4PTGER2CCR1MEN1HTR1A | |
| SCHEMBL6993640 | 0.76 | CCR1 (0.59) | CCR1FPR3GPR65GPR35MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326867-A2 | BRIDGED PIPERAZINE DERIVATIVES | Pfizer Products Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032901-A2 | BRIDGED PIPERAZINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2002-04-25 | — | — | WO | disclosed |