Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226594 | 0.78 | CYP3A4 (0.68) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL9181688 | 0.76 | KMT2A (0.58) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL9179657 | 0.73 | MAPT (0.54) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL27535690 | 0.72 | KCNA3 (0.55) | LMNAMEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL9179528 | 0.72 | ABCB1 (0.54) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL7007007 | 0.71 | CYP3A4 (0.44) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7711797 | 0.71 | MEN1 (0.48) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7705260 | 0.70 | PRMT5 (0.44) | LMNAMEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL7711594 | 0.70 | LMNA (0.47) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7600203 | 0.70 | KMT2A (1.00) | LMNAMEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339701-A1 | HETEROARYL ALKYL PIPERAZINE DERIVATIVES AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002064576-A1 | HETEROARYL ALKYL PIPERAZINE DERIVATIVES AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2002-08-22 | — | — | WO | disclosed |