Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 8/20 | 0.66 |
| ▸ | HTR1A | P08908 | 5/20 | 0.50 |
| ▸ | HTR1D | P28221 | 4/20 | 0.50 |
| ▸ | HTR1B | P28222 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009808 | 0.95 | HTR1F (0.62) | HTR1FHTR1AHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7011710 | 0.94 | HTR1F (0.76) | HTR1FHTR1AHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7009440 | 0.91 | HTR1F (0.58) | HTR1FHTR1AHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7015438 | 0.91 | HTR1F (0.58) | HTR1FHTR1AHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7008625 | 0.90 | HTR1F (0.75) | HTR1FHTR1AHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7011190 | 0.90 | HTR1F (0.57) | HTR1FHTR1AHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7011170 | 0.89 | HTR1F (0.65) | HTR1FHTR1AHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7010825 | 0.89 | HTR1F (0.60) | HTR1FHTR1AHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7009099 | 0.88 | HTR1F (0.56) | HTR1FHTR1AHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7007093 | 0.88 | HTR1F (0.83) | HTR1FHTR1AHTR1DHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842934-B1 | 5-HT1F agonists | LILLY CO ELI (US) | 2003-10-29 | — | — | EP | disclosed |
| EP-1082958-A2 | 5-HT1F agonists in chronic pain | ELI LILLY AND COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| US-5998622-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0842934-A1 | 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-05-20 | — | — | EP | disclosed |