Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 18/20 | 0.75 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324971 | 0.86 | MMP13 (1.00) | MMP13 | |
| SCHEMBL6331916 | 0.83 | MMP13 (0.76) | MMP13MMP2MMP3MMP9 | |
| SCHEMBL6325572 | 0.83 | MMP13 (0.76) | MMP13MMP2MMP3MMP9 | |
| SCHEMBL6327805 | 0.82 | MMP13 (0.68) | MMP13MMP2MMP3MMP9 | |
| SCHEMBL6333972 | 0.81 | MMP13 (0.90) | MMP13 | |
| SCHEMBL6326016 | 0.79 | MMP13 (0.64) | MMP13OPRM1 | |
| SCHEMBL6326080 | 0.79 | MMP13 (0.69) | MMP13 | |
| SCHEMBL6326022 | 0.78 | MMP13 (0.69) | MMP13MMP2MMP3MMP9 | |
| SCHEMBL6325322 | 0.78 | MMP13 (0.69) | MMP13MMP2MMP3MMP9 | |
| SCHEMBL6401032 | 0.77 | MMP13 (0.67) | MMP13MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332146-A2 | SPIRO-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002034753-A2 | SPIRO-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-05-02 | — | — | WO | disclosed |