Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.45 |
| ▸ | EGFR | P00533 | 9/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | WEE2 | P0C1S8 | 1/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999119 | 0.86 | SRC (0.43) | SRCEGFRERBB2GAKMAP3K8 | |
| SCHEMBL4457251 | 0.85 | EGFR (0.53) | SRCEGFRERBB2GAKMAP2K1 | |
| SCHEMBL4453393 | 0.85 | EGFR (0.61) | SRCEGFRERBB2MAP2K1 | |
| SCHEMBL7000865 | 0.82 | SRC (0.43) | SRCEGFRERBB2WEE2WEE1 | |
| SCHEMBL4443477 | 0.81 | EGFR (0.51) | SRCEGFRERBB2GAKMAP2K1 | |
| SCHEMBL6999070 | 0.79 | MAP2K1 (0.56) | SRCEGFRERBB2MAP2K1 | |
| SCHEMBL7000002 | 0.77 | MAP2K1 (0.64) | SRCEGFRERBB2MAP2K1 | |
| SCHEMBL5252441 | 0.76 | EGFR (0.59) | SRCEGFRERBB2MAP3K8 | |
| SCHEMBL7004154 | 0.76 | SRC (0.49) | SRCEGFRERBB2GAK | |
| SCHEMBL7003243 | 0.76 | MAPT (0.48) | SRCEGFRERBB2GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |