Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.58 |
| ▸ | KDR | P35968 | 8/20 | 0.58 |
| ▸ | LCK | P06239 | 7/20 | 0.58 |
| ▸ | TEK | Q02763 | 6/20 | 0.58 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | RET | P07949 | 5/20 | 0.51 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | ABL2 | P42684 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005973 | 0.83 | SRC (0.80) | SRCKDRLCKTEKEGFR | |
| SCHEMBL7004986 | 0.76 | SRC (0.71) | SRCKDRLCKTEKEGFR | |
| SCHEMBL7005163 | 0.76 | SRC (0.81) | SRCKDRLCKTEKEGFR | |
| SCHEMBL13020146 | 0.74 | SRC (0.73) | SRCKDRLCKTEKEGFR | |
| SCHEMBL6861193 | 0.74 | LCK (1.00) | SRCKDRLCKTEKEGFR | |
| SCHEMBL18520776 | 0.73 | LCK (0.70) | SRCKDRLCKTEKEGFR | |
| SCHEMBL7009201 | 0.72 | SRC (0.69) | SRCKDRLCKTEKEGFR | |
| SCHEMBL7005545 | 0.72 | SRC (0.69) | SRCKDRLCKTEKEGFR | |
| SCHEMBL7008786 | 0.71 | ALDH1A1 (0.37) | — | |
| SCHEMBL7012535 | 0.71 | SRC (0.78) | SRCKDRLCKTEKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| EP-0970084-A1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |
| WO-1998041525-A1 | PYRROLO[2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |