Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RPS6KA2 | Q15349 | 4/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865666 | 0.74 | KDM4E (0.49) | PARP10PARP11KDM5BCDC7 | |
| SCHEMBL8232684 | 0.65 | ATR (0.46) | GSK3B | |
| SCHEMBL20878647 | 0.64 | RPS6KA3 (0.34) | RPS6KA3RPS6KA2 | |
| SCHEMBL4868960 | 0.62 | MAPK14 (0.36) | CDC7RPS6KA3CSNK1A1CSNK1DCSNK1E | |
| SCHEMBL31728442 | 0.61 | NSD3 (0.40) | CDC7CSNK1E | |
| SCHEMBL7005018 | 0.60 | KDM4C (0.36) | KDM4CGAAHTT | |
| SCHEMBL4826999 | 0.60 | ALDH1A1 (0.49) | KDM5BCDC7RPS6KA3PDE3BPDE3A | |
| SCHEMBL832273 | 0.59 | MAPT (0.36) | HTTRPS6KA2 | |
| SCHEMBL27512259 | 0.59 | KDM4C (0.48) | GSK3BKDM4CCSNK1A1CSNK1DPDE3B | |
| SCHEMBL4763499 | 0.58 | KDM5A (0.34) | KDM5BCDC7CSNK1ELATS1MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1340761-A1 | Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives | SANOFI-SYNTHELABO (FR) | 2003-09-03 | — | — | EP | disclosed |
| EP-1295885-A1 | Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives | SANOFI-SYNTHELABO (FR) | 2003-03-26 | — | — | EP | disclosed |