Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005581 | 0.87 | EGFR (0.37) | EGFRERBB2MAPK1KDM4EHTT | |
| SCHEMBL6773317 | 0.85 | BRAF (0.53) | EGFRERBB2MAPK1KDM4EHTT | |
| Hydrochloric Acid SCHEMBL6768785 | 0.85 | BRAF (0.52) | EGFRERBB2MAPK1KDM4EHTT | |
| SCHEMBL7010037 | 0.84 | EGFR (0.55) | EGFRERBB2MAPK1KDM4EHTT | |
| SCHEMBL7008227 | 0.81 | ERBB2 (0.65) | EGFRERBB2CLK4 | |
| SCHEMBL7890444 | 0.79 | EGFR (0.47) | EGFRERBB2MAPK1KDM4EHTT | |
| SCHEMBL3321532 | 0.78 | EGFR (0.51) | EGFRERBB2MAPK1KDM4EHTT | |
| Hydrochloric Acid SCHEMBL3320236 | 0.77 | EGFR (0.50) | EGFRERBB2MAPK1KDM4EHTT | |
| SCHEMBL3320152 | 0.77 | ERBB2 (0.58) | EGFRERBB2BRAFHSD17B10 | |
| SCHEMBL3324098 | 0.77 | EGFR (0.57) | EGFRERBB2MAPK1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912572-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2003-01-15 | — | — | EP | disclosed |