Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.50 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008227 | 0.89 | ERBB2 (0.65) | EGFRERBB2ERBB4TTBK1TTBK2 | |
| SCHEMBL6764388 | 0.85 | KDR (0.58) | EGFRRIPK2EPHB2KDRTEK | |
| SCHEMBL7005568 | 0.84 | EGFR (0.45) | EGFRKDRERBB2LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL6766661 | 0.84 | KDR (0.57) | EGFRRIPK2EPHB2KDRTEK | |
| SCHEMBL7009435 | 0.81 | EGFR (0.58) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL6769401 | 0.76 | ERBB2 (0.67) | EGFRERBB2ERBB4JAK3MAPT | |
| SCHEMBL7888611 | 0.76 | KDR (0.66) | EGFRRIPK2EPHB2KDRTEK | |
| SCHEMBL16981193 | 0.76 | EGFR (0.73) | EGFRRIPK2EPHB2KDRTEK | |
| SCHEMBL7886379 | 0.76 | EGFR (0.63) | EGFRRIPK2EPHB2KDRTEK | |
| Hydrochloric Acid SCHEMBL6769685 | 0.75 | ERBB2 (0.66) | EGFRERBB2ERBB4JAK3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912572-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2003-01-15 | — | — | EP | disclosed |