Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15492780 | 0.86 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPPARG | |
| SCHEMBL7003587 | 0.86 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPPARG | |
| SCHEMBL14045898 | 0.82 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7004191 | 0.81 | CRBN (0.55) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7005119 | 0.81 | CRBN (0.55) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL2150685 | 0.80 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL15850421 | 0.80 | KDM4E (0.45) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL13664789 | 0.79 | THRA (0.46) | PDE4APDE4BPDE4CPDE4DPPARG | |
| SCHEMBL15492773 | 0.78 | PPARG (0.50) | PDE4APDE4BPDE4CPDE4DPPARG | |
| SCHEMBL7005161 | 0.78 | PPARG (0.50) | PDE4APDE4BPDE4CPDE4DPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133140-B2 | Cycloalkylamne derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-09-15 | — | — | US | disclosed |
| US-20120295943-A9 | CYCLOALKYLAMINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-22 | — | — | US | disclosed |
| US-20120122941-A1 | CYCLOALKYLAMINE DERIVATIVES | MARUMOTO SHINJI (JP) | 2012-05-17 | — | — | US | disclosed |
| WO-2010021351-A1 | CYCLOALKYLAMINE DERIVATIVE | 第一三共株式会社 (JP) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295943-A9 | CYCLOALKYLAMINE DERIVATIVES | CASR, CALCR, CALCRL | PDE4A 1818/4885PDE4B 1913/4885PDE4C 3068/4885 |
| US-20120122941-A1 | CYCLOALKYLAMINE DERIVATIVES | CASR, CALCR, CALCRL | PDE4A 1818/4885PDE4B 1913/4885PDE4C 3068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.