Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005647 | 1.00 | HTR6 (0.45) | HTR6ALDH1A1KDM4EGAAL3MBTL1 | |
| SCHEMBL7008522 | 0.88 | HTR6 (0.59) | HTR6 | |
| SCHEMBL7008647 | 0.83 | HTR6 (0.50) | HTR6L3MBTL1ALOX5 | |
| SCHEMBL7008649 | 0.83 | HTR6 (0.50) | HTR6L3MBTL1ALOX5 | |
| SCHEMBL7009328 | 0.82 | HTR6 (0.43) | HTR6ALDH1A1KDM4EGAA | |
| SCHEMBL7009333 | 0.82 | HTR6 (0.43) | HTR6ALDH1A1KDM4EGAA | |
| SCHEMBL2065324 | 0.81 | HTR6 (0.45) | HTR6ALDH1A1 | |
| SCHEMBL7005429 | 0.79 | HTR6 (0.58) | HTR6 | |
| SCHEMBL7005431 | 0.79 | HTR6 (0.58) | HTR6 | |
| SCHEMBL7006169 | 0.79 | HTR6 (0.52) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105393-B1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | claimed |
| US-6251893-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | NPS ALLELIX CORP. (CA) | 2001-06-26 | — | — | US | claimed |
| EP-1105393-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2001-06-13 | — | — | EP | claimed |
| WO-1999065906-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1999-12-23 | — | — | WO | claimed |
| EP-1105393-B1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| US-6251893-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | NPS ALLELIX CORP. (CA) | 2001-06-26 | — | — | US | disclosed |
| EP-1105393-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2001-06-13 | — | — | EP | disclosed |
| WO-1999065906-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1999-12-23 | — | — | WO | disclosed |