Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 20/20 | 1.00 |
| ▸ | KCNJ11 | Q14654 | 20/20 | 1.00 |
| ▸ | ABCC8 | Q09428 | 19/20 | 1.00 |
| ▸ | KCNJ8 | Q15842 | 19/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010426 | 0.92 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7095856 | 0.92 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7009886 | 0.92 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7850239 | 0.90 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7095809 | 0.90 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7853133 | 0.90 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL5074865 | 0.89 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7008606 | 0.86 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7014635 | 0.84 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7100230 | 0.78 | ABCC9 (0.76) | ABCC9KCNJ11ABCC8KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |