Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ADK | P55263 | 3/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30046665 | 0.90 | DGAT1 (0.56) | DGAT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL2424040 | 0.81 | DGAT1 (0.62) | DGAT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL30046676 | 0.81 | DGAT1 (0.62) | DGAT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL30782543 | 0.81 | DGAT1 (0.62) | DGAT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL30046414 | 0.80 | DGAT1 (0.61) | DGAT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL20522402 | 0.80 | DGAT1 (0.61) | DGAT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1270834 | 0.80 | KDM4E (0.64) | DGAT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6068337 | 0.80 | DGAT1 (0.61) | DGAT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL27454250 | 0.78 | DGAT1 (0.58) | DGAT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL30046803 | 0.78 | DGAT1 (0.77) | DGAT1MEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |